Papel de los antioxidantes en la prevención del cáncer
DOI:
https://doi.org/10.14306/renhyd.16.1.102Palabras clave:
Cáncer, Radicales libres, Antioxidantes, Lisozima, GlutatiónResumen
La naturaleza de la asociación entre radicales libres y cáncer es compleja y paradójica. Parece que los radicales libres y el estrés oxidativo pueden inducir cáncer, pero al mismo tiempo las células transformadas, es decir, las células cancerosas, generan más radicales libres que las células normales. Compuestos endógenos antioxidantes, entre ellos el glutatión y la lisozima, pueden limitar los efectos del estrés oxidativo; sin embargo, dichos sistemas pueden ser rápidamente acaparados por elevadas cantidades de radicales libres. De ahí la importancia de incrementar la concentración de antioxidantes de la célula para prevenir posibles agentes adversos que podrían llegar a originar un proceso canceroso. Una buena alimentación, así como conocer y emplear alimentos con propiedades antioxidantes, puede ser de gran ayuda para la prevención del cáncer.Descargas
Citas
Adachi M, Zhang Y, Zhao X, Minami T, Kawamura R, Hinoda Y, et al. Clin Cancer Res. 2004;10:3853-62. DOI: https://doi.org/10.1158/1078-0432.CCR-03-0806
Anand P, Kunnumakkara AB, Kunnumakara AB, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25:2097-116. DOI: https://doi.org/10.1007/s11095-008-9661-9
Kinzler KW, Vogelstein B. The genetic basis of human cancer 2.a ed. New York: McGraw-Hill; 2002. p. 5.
Irigaray P, Newby JA, Clapp R, et al. Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed Pharmacother. 2007;61:640-58. DOI: https://doi.org/10.1016/j.biopha.2007.10.006
Matill HA. Antioxidants. Annu Rev Biochem. 1947;16:177-92. DOI: https://doi.org/10.1146/annurev.bi.16.070147.001141
Roche E, Romero D. Estrés oxidativo y degradación de proteínas. Med Clin (Barc). 1994;103:189-96.
Cotran RS, et al. Patología estructural y funcional. 5.a ed. Mc-Graw-Hill/Interamericana.
Martins MA, et al. Interaction between infl ammation and systemic haematologic effect of PAF-acether in the rat. L Pharmacol. 1989;36:333-60.
Jiménez S. Antioxidantes y RL en el tabaquismo. Buenos Aires: Solo-Mujeres; 2003.
Knight J. Free radicals: their history and current status in aging and disease. Ann Clin Lab Sci. 28:331-46.
Coulter I, Hardy M, Morton S, Hilton L, Tu W, Valentine D, et al. Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer. J Gen Intern Med. 2007;21:735-44. DOI: https://doi.org/10.1111/j.1525-1497.2006.00483.x
Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, et al. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-κB. J Biol Chem. 1999;274:27891-7. DOI: https://doi.org/10.1074/jbc.274.39.27891
Perez-Galan P, Roue G, Villamar N, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantlecell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood. 2006;107:257-64. DOI: https://doi.org/10.1182/blood-2005-05-2091
Atalla S, Toledo-Pereya LH, McKenzie GH, Cederna JP. Influence of oxygen-derived free scavengers. Transplantation. 1985;40:584-90. DOI: https://doi.org/10.1097/00007890-198512000-00002
McWen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998 Jan 15;338(3):171-9. DOI: https://doi.org/10.1056/NEJM199801153380307
De Ross AJ, et al. Cancer incident among Glyphosate-Exposed Pesticida Applicators in the Agricultural Health Study. Environ Health Perspect. 2005;113:49-54.
Shimosawa T. [Increasing oxidative stress in aging]. Nippon Rinsho. 2005;63:994-9.
Southern PA, Powis G. Medicine. II. Involvement in human disease. Mayo Clin Proc. 1994;63:390-404. DOI: https://doi.org/10.1016/S0025-6196(12)64862-9
Altamar J. Herbicidas y Malf. Congén. en el Meta, Colombia. Actividad Patogénica de los RL. Orinoquia, Villavicencio, Colombia, 2002; 6:9-35.
Guyton AC, et al. Tratado de Fisiología. 9.a ed. México: Mc-Graw-Hill/Interamericana; 1997.
Villa Pérez M. RL de O2 y la enfermedad. Conferencia en la VI Reunión del Grupo Español de RL. Cádiz, 26-28 de Junio de 2002.
De Ross AJ, et al. Cancer incidente among Glyphosate-Exposed Pesticida Applicators in the Agricultural Health Study. Environ Health Perspect. 2005;113:49-54. DOI: https://doi.org/10.1289/ehp.7340
Hallivell B. Current review. Free reactive oxygen species human disease, a critical evaluation with special reference to aterosclerosis. B Exp Path. 1995;70:737-57.
Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005;39:359-407. DOI: https://doi.org/10.1146/annurev.genet.39.110304.095751
Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J, et al. Proc Natl Acad Sci U S A. 2005;102:719-24. DOI: https://doi.org/10.1073/pnas.0408894102
Szatrowski TP, Nathan CF. Cancer Res. 1991;51:794-8.
Schumacker P. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell. 2006;10:175-6. DOI: https://doi.org/10.1016/j.ccr.2006.08.015
Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008;8:967-75. DOI: https://doi.org/10.1038/nrc2540
Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorogenesis. Cell Death Differ. 2008;15:678-85. DOI: https://doi.org/10.1038/cdd.2008.21
Denko NC. Hypoxia, HIF1 and glucosa metabolism in the solid tumor. Nat Rev Cancer. 2008;8:705-13. DOI: https://doi.org/10.1038/nrc2468
Guzy RD, Hoyos B, Robin E, et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 2005;1:401-8. DOI: https://doi.org/10.1016/j.cmet.2005.05.001
Lluis JM, Buricchi F, Chiarugi P, Morales A, Fernandez-Checa JC. Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-kappa B via c-SRC and oxidant-dependent cell death. Cancer Res. 2007;67:7368-77. DOI: https://doi.org/10.1158/0008-5472.CAN-07-0515
Han D, Hanawa N, Saberi B, Kaplowitz N. Mechanisms of liver injury. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1-7. DOI: https://doi.org/10.1152/ajpgi.00001.2006
Altamar J. The role of lysozime on etiopathogenesis and treatment on juvenile laryngeal papillomatosis. Otolaryngol Torino. 1998;44:17-20.
Bjelakovic G, Gluud LL, Nikolova D, Bjelakovic M, Nagorni A, Gluud C. Antioxidant supplements for liver diseases. Cochrane Database Syst Rev. 2011;(3):CD007749. DOI: https://doi.org/10.1002/14651858.CD007749.pub2
Cranganu A, Camporeale J. Nutrition aspects of lung cancer. Nutr Clin Pract. 2009;24:688-700. DOI: https://doi.org/10.1177/0884533609352249
Persson C, Sasazuki S, Inoue M, Kurahashi N, Iwasaki M, Miura T, et al. Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study. Carcinogenesis. 2008;29:1042-8. DOI: https://doi.org/10.1093/carcin/bgn072
Charniot JC, Vignat N, Albertini JP, Bogdanova V, Zerhouni K, Monsuez JJ, et al. Oxidative stress in patients with acute heart failure. Rejuvenation Res. 2008;11:393-8. DOI: https://doi.org/10.1089/rej.2008.0663
Eledrisi MS, McKinney K, Shanti MS. Vitamin A toxicity [citado 2 Sep 2009]. Disponible en: http://emedicine.medscape.com/article/126104-overview
Litwack G. Vitamin A. Vitamins and hormones. Elsevier; 2007.
Wilson LG. The clinical defi nition of scurvy and the discovery of vitamin C. J Hist Med. 1975;40-60. DOI: https://doi.org/10.1093/jhmas/XXX.1.40
Challem JJ, Taylor EW. Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens. Free Radical Biology and Medicine. 1998;25:130-2. DOI: https://doi.org/10.1016/S0891-5849(98)00034-3
Bánhegyi G, Braun L, Csala M, Puskás F, Mandl J. Ascorbate metabolism and its regulation in animals. Free Radical Biology and Medicine. 1997;23:793-803. DOI: https://doi.org/10.1016/S0891-5849(97)00062-2
Villamor E, Koulinska IN, Aboud S, Murrin C, Bosch RJ, Manji KP, et al. Effect of vitamin supplements on HIV shedding in breast milk. Am J Clin Nutr. 2010;92:881-6. DOI: https://doi.org/10.3945/ajcn.2010.29339
Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci. 2001;98:11720-4. DOI: https://doi.org/10.1073/pnas.171325998
Ichim TE, Minev B, Braciak T, Luna B, Hunninghake R, Mikirova NA, et al. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? J Transl Med. 2011;9:25. DOI: https://doi.org/10.1186/1479-5876-9-25
Institute of Medicine, Food and Nutrition board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington: National Academy Press; 2000.
Rosenberg H, Feldzamen AN. The book of vitamin therapy. New York: Berkley; 1974.
Balendiran GK, Dabur R, Fraser D. The role of glutathione in cancer. Cell Biochem Funct. 2004;22:343-52.
Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol. 2003;66:1499-503. DOI: https://doi.org/10.1016/S0006-2952(03)00504-5
Bounous G, Gold P. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med. 1991;14:296-309.
Meister A, Yaniguchi N, Higashi T, Sakamoto Y. Glutathione centennial. San Diego: Academic Press; 1989. p. 3-21. DOI: https://doi.org/10.1016/B978-0-12-683275-4.50005-X
Griffi th O, Meister A. Potent and specifi c inhibition of glutathione synthesis by buthionine sulfoximine. J Biol Chem. 1979;254:7558-60. DOI: https://doi.org/10.1016/S0021-9258(18)35980-5
Meister A. Glutathione metabolism. Methods Enzymol Rev. 1995;251:3-7. DOI: https://doi.org/10.1016/0076-6879(95)51106-7
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489-92. DOI: https://doi.org/10.1093/jn/134.3.489
Cooper A. Biochemistry of sulfur-containing amino acids. Annu Rev Biochem. 1983;52:187-222. DOI: https://doi.org/10.1146/annurev.bi.52.070183.001155
Wahllander A, Soboll A, Sies H. Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S- transferases. FEBS Lett. 1975;97:138-40. DOI: https://doi.org/10.1016/0014-5793(79)80069-1
García-Ruiz C, Morales A, Colell A, Ballesta A, Rodés J, Kaplowitz N, et al. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest. 1994;94:193-201. DOI: https://doi.org/10.1172/JCI117306
Sa G, Das T, Moon C, et al. GD3, an overexpressed tumor-derived ganglioside, mediates apoptosis of activated but not resting T cells. Cancer Res. 2009;69:3095-104. DOI: https://doi.org/10.1158/0008-5472.CAN-08-3776
Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43:667-9. DOI: https://doi.org/10.1007/BF02284971
Liber CS. S-Adenosyl-L-methionine: its role in the treatment of liver disorders. Am J Clin Nutr. 2002;76:S1183-7. DOI: https://doi.org/10.1093/ajcn/76.5.1183S
Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989;24:407-15. DOI: https://doi.org/10.3109/00365528909093067
Loguercio C, Nardi G, Argenzio F, Aurilio C, Petrone E, Grella A, et al. Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease. Alcohol Alcohol. 1994;29:597-604.
Gross CL, Innace JK, Hovatter RC, Meier HL, Smith WJ. Biochemical manipulation of intracellular glutathione levels infl uences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol. 1993;9:259-67. DOI: https://doi.org/10.1007/BF00755604
Moreno YF, Sgarbieri VC, Da Silva MN, Toro AA, Vilela MM. Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection. J Trop Pediatr. 2006;52:34-8. DOI: https://doi.org/10.1093/tropej/fmi074
Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LC. Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibros. 2003;2:195-8. DOI: https://doi.org/10.1016/S1569-1993(03)00097-3
Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIVinfected patients. Eur J Nutr. 2002;41:12-8. DOI: https://doi.org/10.1007/s003940200001
Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med. 1993;16:204-9.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790:1149-60. DOI: https://doi.org/10.1016/j.bbagen.2009.07.026
Busse E, Zimmer G, Schopohl B, Kornhuber B. Infl uence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung. 1992;42:829-31.
Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD, et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int. 1995;26:497-502. DOI: https://doi.org/10.1016/0197-0186(94)00154-M
Nencini C, Giorgi G, Micheli L. Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine. 2007;14:129-35. DOI: https://doi.org/10.1016/j.phymed.2006.02.005
Valenzuela A, Aspillaga M, Vial S, Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med. 1989;55:420-2. DOI: https://doi.org/10.1055/s-2006-962056
[sede web]. Immunocal Powder Sachets patient advice including side effects. Disponible en: http://www.drugs.com/drp/immunocal-powder-sachets.html
Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, et al. Glutathione defi ciency is associated with impaired survival in HIV disease. Proc Natl Acad Sci U S A. 1997;94:1967-72. DOI: https://doi.org/10.1073/pnas.94.5.1967
Han YH, Park WH. The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. Oncol Rep. 2009;22:385-91. DOI: https://doi.org/10.3892/or_00000449
Chow HH, Hakim IA. Modulation of human glutathione s-transferases by polyphenone intervention. Cancer Epidemiol Biomarkers Prev. 2007;16:1662-6. DOI: https://doi.org/10.1158/1055-9965.EPI-06-0830
Balendiran GK, Dabur R, Fraser D. The role of glutathione in cancer. Cell Biochem Funct. 2004;22:343-52. DOI: https://doi.org/10.1002/cbf.1149
Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol. 2011;31:95-107. DOI: https://doi.org/10.1002/jat.1649
Ambrozova G, Pekarova M, Lojek A. The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Toxicol In Vitro. 2011;25:145-52. DOI: https://doi.org/10.1016/j.tiv.2010.10.006
Rammal H, Bouayed J, Younos C, Soulimani R. Evidence that oxidative stress is linked to anxiety-related behaviour in mice. Brain Behav Immun. 2008;22:1156-9. DOI: https://doi.org/10.1016/j.bbi.2008.06.005
Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst. 1995;87:1767-76. DOI: https://doi.org/10.1093/jnci/87.23.1767
Giovannucci E, Willett WC, Stampfer MJ, Liu Y, Rimm EB. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst. 2002;94:391-6. DOI: https://doi.org/10.1093/jnci/94.5.391
Woodside J, McCall D, McGartland C, Young I. Micronutrients: dietary intake v. supplement use. Proc Nutr Soc. 2005;64:543-53. DOI: https://doi.org/10.1079/PNS2005464
Cao G, Prior R. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem. 1998;44 (6 Pt 1):1309-15. DOI: https://doi.org/10.1093/clinchem/44.6.1309
Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004;9:136-56.
Pocernich CB, Bader Lange ML, Sultana R, Butterfi eld DA. Nutritional approaches to modulate oxidative stress in Alzheimer’s disease. Curr Alzheimer Res. 2011;8:452-69. DOI: https://doi.org/10.2174/156720511796391908
Lee KJ, Choi CY, Chung YC, Kim YS, Ryu SY, Roh SH, et al. Protective effect of saponins derived from roots of Platycodon grandifl orum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol Lett. 2004;147:271-82. DOI: https://doi.org/10.1016/j.toxlet.2003.12.002
Banni M, Chouchene L, Said K, Kerkeni A, Messaoudi I. Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafi sh Danio rerio. Biometals. 2011. DOI: https://doi.org/10.1007/s10534-011-9456-z
Kim JH, Kim BW, Kwon HJ, Nam SW. Curative effect of selenium against indomethacin-induced gastric ulcers in rats. J Microbiol Biotechnol. 2011;21:400-4. DOI: https://doi.org/10.4014/jmb.1012.12019




