Consideraciones metodológicas sobre el estudio de la dieta y los niveles fecales de Akkermansia muciniphila en adultos mayores

(1) Tume F, Palma-Gutierrez EJ, Mamani-Urrutia V, Requena F, Ruiz J. Diet, anthropometric measurements, sleep quality and fecal levels of Akkermansia muciniphila: a cross-sectional study in older adults. Rev Esp Nutr Hum Diet. 2026;30(1):e2596. doi:10.14306/renhyd.30.1.2596. DOI: https://doi.org/10.14306/renhyd.30.1.2596

(2) Ioannou A, Berkhout MD, Geerlings SY, Belzer C. Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential. Nat Rev Microbiol. 2025;23(3):162-177. doi:10.1038/s41579-024-01106-1. DOI: https://doi.org/10.1038/s41579-024-01106-1

(3) Osman MA, Neoh HM, Ab Mutalib NS, Chin SF, Mazlan L, Raja Ali RA, et al. Parvimonas micra, Peptostreptococcus stomatis, Fusobacterium nucleatum and Akkermansia muciniphila as a four-bacteria biomarker panel of colorectal cancer. Sci Rep. 2021;11(1):2925. doi:10.1038/s41598-021-82465-0. DOI: https://doi.org/10.1038/s41598-021-82465-0

(4) Sezgin E, Terlemez G, Bozkurt B, Bengi G, Akpinar H, Büyüktorun İ. Quantitative real-time PCR analysis of bacterial biomarkers enables fast and accurate monitoring in inflammatory bowel disease. PeerJ. 2022;10:e14217. doi:10.7717/peerj.14217. DOI: https://doi.org/10.7717/peerj.14217

(5) Quince C, Walker AW, Simpson JT, Loman NJ, Segata N. Shotgun metagenomics, from sampling to analysis. Nat Biotechnol. 2017;35(9):833-844. doi:10.1038/nbt.3935. DOI: https://doi.org/10.1038/nbt.3935

(6) Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-specific anti-inflammatory properties of two Akkermansia muciniphila strains on chronic colitis in mice. Front Cell Infect Microbiol. 2019;9:239. doi:10.3389/fcimb.2019.00239. DOI: https://doi.org/10.3389/fcimb.2019.00239

(7) Lerma-Aguilera AM, Pérez-Burillo S, Navajas-Porras B, León ED, Ruíz-Pérez S, Pastoriza S, et al. Effects of different foods and cooking methods on the gut microbiota: an in vitro approach. Front Microbiol. 2024;14:1334623. doi:10.3389/fmicb.2023.1334623. DOI: https://doi.org/10.3389/fmicb.2023.1334623

(8) Johnson AJ, Mueller NT. Can data-driven approaches for dietary pattern assessment improve microbiome epidemiology research? Am J Clin Nutr. 2022;115(2):329-331. doi:10.1093/ajcn/nqab386. DOI: https://doi.org/10.1093/ajcn/nqab386